Abstract：Previous studies reported that schizophrenia patients with auditory verbal hallucinations(AVHs) demonstrated structural network impairment,functional network disturbance,cerebral blood disturbance and neural metabolism disturbance.The findings of aforementioned studies enhanced our understanding about the pathological mechanisms of AVHs.However,if the brain imaging characters which related to the AVHs symptom will development following the time or illness duration? How the dynamically developmental trajectories of brain imaging characters which related to the AVHs symptom will be demonstrated? which relationship between the brain iamging characters and the therapeutic effects and outcomes will be demonstrated? Which brain imaging characters can predict the therapeutic effects and provide objective indices to help the precision treatment? To achieve this aim,we must conduct a longitudinal study which adopt multimodality techniques,recruiting the first-episode schizophrenia patients with AVHs,analyze the dynamically developmental trajectories of the brain imaging characters related to AVHs from multiple perspectives and the relationship between the brain characters and therapeutic outcomes will help us to explain above mentioned questions.
张津津1曲鸿儒1高艳杰1马晓雷1崔明伟1徐庆迎1刘艳艳1禚传君1，2. 言语性幻听症状的多模态脑影像学研究现状及未来趋势[J]. 中华诊断学电子杂志, 2016, 4(2): 100-.
Zhang Jinjin1,Qu Hongru1,Gao Yanjie1,Ma Xiaolei1,Cui Mingwei1,Xu Qingying1,Liu Yanyan1,Zhuo Chuanjun1，2. The research status and future trends of multimodal brain images on patients with auditory verbal hallucinations. zhzdx, 2016, 4(2): 100-.
