禚传君1 Patrick Triplett 2Andrea Ciprini 3Rachel Upthegrove4
300222天津医科大学精神卫生研究室天津市精神卫生中心天津市安定医院1；21287-7419Maryland，Johns Hopkins UniversityPsychiatry and Behavioral Sciences2；OX3 7JXUniversity of OxfordPsychiatry3；B152FGUniversity of BirminghamPsychiatry4
An overview of the study about early qualitative diagnosis of the schizophrenia comorbid with depression based on multi-modal brain imaging
Zhuo Chuanjun1 Patrick Triplett 2Andrea Ciprini 3Rachel Upthegrove4
1Department of Psychiatry, Tianjin Medical University, Tianjin Mental Health Center, Tianjin Anding Hospital, Tianjin 300222, China；2Department of Psychiatry and Behavioral Sciences,the Johns Hopkins Hospital,600 North Wolfe Street, Meyer 4-119.Baltimore, MD 21287-7419, USA；3 Department of Psychiatry, Warneford Hospital,University of Oxford,OX3 7JX,UK;4Department of Psychiatry,University of Birmingham,Birmingham B152FG,UK
Abstract：Depressive symptoms could occur at any stage in the course of schizophrenia,and seriously damages the prognosis of schizophrenia.There are great differences in symptoms between depressive symptoms in schizophrenia and the clinical symptoms of simple depression, and so are in the treatment effect.A variety of evidence suggests that there may be a special sub-type of schizophrenia, which could be named depression-schizophrenia.This sub-type can be reflected in the specific brain features,which can be characterized by brain imaging techniques.Based on the above reasons and our previous studies,we intend to enroll the primary episode schizophrenia patients in a follow-up study,using multi-modal brain imaging and pattern recognition technologies,comparing the differences of the brain figures between the schizophrenia patients with or without depression,to reveal the specific brain characters of the depression-schizophrenia.At last we airn to reveal the specific therapeutic targets,set up the predict index and effect model which could provide an objective basis for the early precise diagnosis and individual treatment of the depression-schizophrenia.
禚传君 Patrick Triplett Andrea Ciprini Rachel Upthegrove. 基于脑影像和机器学习的抑郁型精神分裂症早期定性诊断预测模型展望[J]. 中华诊断学电子杂志, 2018, 6(1): 1-8.
Zhuo Chuanjun. An overview of the study about early qualitative diagnosis of the schizophrenia comorbid with depression based on multi-modal brain imaging. zhzdx, 2018, 6(1): 1-8.
