Diagnostic value on the qualitative diagnosis of the different ways of TI-RADS 4 category thyroid nodules less than or equal to 1cm
Wu Han1, Wang Yunji2, Cai Shang3, Jiang Xuan4, Zhu Yuxiang5, Yan Caifeng1, Feng Shangyong1
1Department of Endocrinology and Metabolism, 4Department of Ultrasound, 5Department of General Surgery, Northern Jiangsu People′s Hospital Affiliated to Yangzhou University, Yangzhou 225001, China; 2First Clinical Medical College, Dalian Medical University, Dalian 116044, China; 3Department of Oncology Radiotherapy, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China
Abstract：ObjectiveTo compare the diagnostic value of ultrasound-guided fine needle aspiration cytology (UG-FNAC) combined with BRAFV600E gene mutation and contrastenhanced ultrasound (CEUS) for thyroid imaging reporting and data system (TI-RADS) type 4 thyroid nodules less than or equal to 1cm. MethodsFrom January 2017 to December 2019, 98 patients with 105 TI-RADS type 4 thyroid nodules less than or equal to 1cm confirmed by surgery and pathological examination in Northern Jiangsu People′s Hospital Affiliated to Yangzhou University were analyzed, UG-FNAC, BRAFV600E and CEUS were performed before surgery. The results were compared with surgical pathology which regarded as the "gold standard". ResultsThe diagnostic rates of malignancy (number of malignancy) were 63.81%(67/105), 43.81%(46/105), 55.24%(58/105), 66.67%(70/105), and 53.33%(56/105) for histopathology of surgery, UG-FNAC, UG-FNAC combined with BRAFV600E, CEUS, UG-FNAC and BRAFV600E combined with CEUS, respectively, and all malignant nodules were papillary thyroid microcarcinoma (PTMC). The sensitivities of UG-FNAC, UG-FNAC combined with BRAFV600E, CEUS, UGFNAC and BRAFV600E combined with CEUS were 67.16%, 83.58%, 86.57%, 83.58%, and the specificities were 97.37%, 94.74%, 68.42%, 100.00%, respectively. The Kappa values of UG-FNAC, UG-FNAC combined with BRAFV600E, CEUS, UG-FNAC and BRAFV600E combined with CEUS were 0.58, 0.75, 0.56, 0.79, and the areas under the curve of receiver operating characteristic (ROC) were 0.823, 0.892, 0.775, 0.918 (all P＜0.05), respectively. ConclusionUG-FNAC and BRAFV600E combined with CEUS has higher accuracy and diagnostic value in the diagnosis of TI-RADS type 4 thyroid nodules less than or equal to 1cm.
吴寒 汪耘吉 蔡尚 蒋煊 祝玉祥 闫彩凤 冯尚勇. 不同方法对甲状腺影像学报告及数据系统
4类直径≤1cm结节良恶性的诊断价值[J]. 中华诊断学电子杂志, 2021, 9(4): 232-236.
Wu Han1, Wang Yunji2, Cai Shang3, Jiang Xuan4, Zhu Yuxiang5, Yan Caifeng1, Feng Shangyong1. Diagnostic value on the qualitative diagnosis of the different ways of TI-RADS 4 category thyroid nodules less than or equal to 1cm. zhzdx, 2021, 9(4): 232-236.
