Research progress of cathepsin B in cardiovascular diseases
Zhou Yu1, Yan Bo2
1Clinical Medical College，Jining Medical University, Jining 272013,China; 2Shandong Provincial Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining 272029,China
Abstract：Previous studies have shown that cathepsins are proteolytic enzymes that mediate protein hydrolysis in endosomes or lysosomes. Recently, accumulating studies have revealed that cathepsins also exist in the nucleus, cytoplasm, plasma membrane, and extracellular matrixes to mediate extracellular matrix protein degradation, signal transduction, and organelle protein processing and transport. Cathepsin B (CTSB) is one of the most abundant cathepsins in lysosomes, usually exists in the form of inactivated proenzyme, and has dual roles of endopeptidase and dipeptidase, which plays an important role in protein catabolism. In recent years, human studies and animal experiments have demonstrated that CTSB involves in many physiological and pathophysiological processes, such as extracellular matrix protein degradation, antigen presentation, and inflammatory body activation. These processes have been directly or indirectly implicated in the pathogenesis of cardiovascular diseases, including atherosclerosis, myocardial infarction and abdominal aortic aneurysm. And now, a large number of studies have found that SARS-CoV-2 enters host target cells through CTSB mediated pathway and leads to cell damage.The purpose of this review is to summarize the biological function of CTSB and related recent progress in cardiovascular diseases.
周瑜 闫波. 组织蛋白酶B在心血管疾病中的研究进展[J]. 中华诊断学电子杂志, 2021, 9(4): 278-281.
Zhou Yu1, Yan Bo2. Research progress of cathepsin B in cardiovascular diseases. zhzdx, 2021, 9(4): 278-281.
