Abstract：ObjectiveTo explore the clinicopathological features of Langerhans cell histiocytosis（LCH）. MethodsThe clinical data of 5 LCH patients who were diagnosed from January 2016 to September 2021 in the Pathology Department at Taian City Center Hospital were analyzed retrospectively, and the pathological characteristics and immunophenotype were analyzed. ResultsThere were 2 males and 3 females patients. Three cases involved bone, 1 case involved oral soft tissue, and 1 case involved the lymph node. The tumor cells had a round or oval shape with a nucleated sulcus, and a weakly eosinophilic cytoplasm, with varied amounts of neutrophils, histiocytes, tiny lymphocytes, and eosinophils in the background. Tumor cells consistently expressed CD4, CD1α and S-100 according to their immunophenotype. ConclusionsLCH, a rare Langerhans cell proliferative lesion, has a stable immunohistochemistry expression. By choosing the proper immunohistochemistry antibody and combining it with pathomorphological markers, the correct diagnosis can be obtained.
