线粒体功能障碍与卵巢早衰的研究进展

doi:10.3877/cma.j.issn.2095-655X.2023.04.013

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摘要卵巢早衰（POF）是一种常见的生殖内分泌疾病，主要表现为因卵巢功能衰竭所致的提前闭经，严重影响女性健康。线粒体作为重要细胞器，不仅具有供能作用，还参与细胞分化、信息传递和凋亡等各种生命活动，其功能障碍与POF发生有关。笔者主要从线粒体能量代谢失衡、线粒体钙代谢失衡、线粒体DNA突变及线粒体动力学改变4个方面综述线粒体异常对POF的影响，并通过总结该疾病的相关机制，对POF的治疗方案作出相应见解及未来展望。

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关键词 ：卵巢早衰, 线粒体DNA, 线粒体能量代谢, 钙代谢, 线粒体动力学

Abstract：Premature ovarian failure (POF) is a common reproductive endocrine disorder that mostly appears as premature amenorrhea due to ovarian failure and has a significant negative impact on the health of women. As significant organelles, mitochondria play multiple roles in a variety of biological processes, including cell development, information transmission, and apoptosis, whose malfunction is thought to result in the occurrence of POF. The authors mainly investigate the consequences of mitochondrial abnormalities on POF from 4 viewpoints, namely, imbalanced mitochondrial energy metabolism, imbalanced mitochondrial calcium metabolism, mitochondrial DNA mutation, and mitochondrial dynamics changes. By outlining the disease′s pertinent mechanism, the treatment plan for POF is evaluated together with its future prospects.

Key words： Premature ovarian failure Mitochondrial DNA Mitochondrial energy metabolism Calcium metabolism Mitochondrial dynamics

收稿日期: 2022-09-22

基金资助:山东省自然科学基金青年基金项目(ZR2021QB124);日照市自然科学基金优秀青年基金项目(海外)(RZ2021ZR1)

通讯作者: 李瑞基， Email：li-ruiji@mail.jnmc.edu.cn

引用本文:

于乾雪1廖学梅2孙龙龙2范梦莹2蒋明超2孟慧1李瑞基3. 线粒体功能障碍与卵巢早衰的研究进展[J]. 中华诊断学电子杂志, 2023, 11(4): 283-288.
Yu Qianxue1, Liao Xuemei2, Sun Longlong2, Fan Mengying2, Jiang Mingchao2, Meng Hui1, Li Ruiji3. . Research progress of mitochondrial dysfunction and premature ovarian failure. zhzdx, 2023, 11(4): 283-288.

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http://www.zhzdxzz.com/CN/10.3877/cma.j.issn.2095-655X.2023.04.013 或 http://www.zhzdxzz.com/CN/Y2023/V11/I4/283

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