Abstract：ObjectiveTo investigate the diagnostic features of Blymphoblastic lymphoma (B-LBL) with facial mass as the first symptom. MethodsThe clinical data of a BLBL patient admitted to the Department of Maxillofacial Surgery, the First Affiliated Hospital of Harbin Medical University on March 5, 2021, were retrospectively analyzed, and the relevant literatures were reviewed. ResultsA female patient, 52, was taken to the hospital after 20 days of right face edema that had no apparent explanation. Right suborbital edema was evident, and palpation revealed a mass with a diameter of approximately 5cm. Leukocytes were 1698×109/L in peripheral blood, and lactate dehydrogenase was 754.6U/L. MRI of the skull revealed thickening of the right maxillofacial soft tissue, as well as lesions of the right maxillary sinus, right temporal muscle, and right turbinate. Doppler ultrasound of the abdomen revealed abdominal effusion was discovered. PET/CT imaging revealed a soft tissue mass in the right maxillofacial region with increased 18F-deoxyglucose (FDG) uptake. Ascites cytology revealed tumor cells (predisposed to nonHodgkin′s lymphoma); Hodgkin′s immunohistochemical staining revealed terminal deoxynucleotide transferase (TdT)(partial cell +), paired box 5(PAX-5)(+), CD79a(+), proliferating cell nuclear antigen (Ki-67)(+90%), and CD10(+), all of which were consistent with nonHodgkin′s BLBL/BALL. ConclusionsBLBL clinical manifestations lack specificity, making it easy to misdiagnose or missed diagnose. Pathological diagnosis and specific immunohistochemical staining of TdT are useful in determining BLBL.
华威 鹿芃恬 李丹阳 吴鹤. 以面部肿物首发的B淋巴母细胞淋巴瘤的诊断学特征并文献复习[J]. 中华诊断学电子杂志, 2022, 10(3): 187-192.
Hua Wei, Lu Pengtian, Li Danyang, Wu He. Diagnostic features of B-lymphoblastic lymphoma with facial mass as the first symptom and literature review. zhzdx, 2022, 10(3): 187-192.
