食管鳞状上皮内瘤变诊断的生物标志物研究进展及其非内镜治疗现状

doi:10.3877/cma.j.issn.2095-655X.2024.04.013

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摘要食管癌是最常见的消化系统恶性肿瘤之一，食管鳞状上皮内瘤变（ESIN）被公认为是食管鳞状细胞癌的癌前病变。因此，癌前的诊断与治疗成为预防食管癌的关键环节。目前，内窥镜检查及治疗是检测与诊治ESIN的主要手段。然而，至今临床上尚未推广应用特异性生物标志物，也缺乏有效治疗ESIN的药物。近些年来，针对上述问题的研究不断开展并向前推进，部分生物标志物和非内镜治疗方法在ESIN的诊治方面显示出潜在价值。笔者旨在对这些研究进展进行全面梳理和综述，以期为食管癌的早期防治提供有益参考。

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关键词 ：食管鳞状上皮内瘤变, 生物标记, 食管肿瘤, 生活方式, 药物治疗

Abstract：Esophageal cancer is one of the most common malignant tumors of the digestive system, and esophageal squamous intraepithelial neoplasia (ESIN) is widely recognized as a precancerous lesion of esophageal squamous cell carcinoma. Consequently, the diagnosis and treatment of these precancerous conditions are pivotal in the prevention of esophageal cancer. At present, endoscopic examination and treatment are the main means to detect, diagnose and treat ESIN. However, to date, specific biomarkers have not been widely promoted for clinical application, and there is a lack of effective medication for the treatment of ESIN. In recent years, research on the above issues has been continuously carried out and advanced, and some biomarkers and non-endoscopic treatment methods have shown potential value in the diagnosis and treatment of ESIN. The purpose of this paper is to comprehensively review and summarize these research advancements, with the aim of providing valuable references for the early prevention and treatment of esophageal cancer.

Key words： Esophageal squamous intraepithelial neoplasia Biomarkers Esophageal neoplasms Life style Drug therapy

收稿日期: 2024-06-30

通讯作者: 樊丽娟， Email： fanlijuan521@126.com

引用本文:

胡瑞芳樊丽娟. 食管鳞状上皮内瘤变诊断的生物标志物研究进展及其非内镜治疗现状[J]. 中华诊断学电子杂志, 2024, 12(4): 281-286.
Hu Ruifang1, Fan Lijuan2.. Research progress on diagnostic biomarkers of esophageal squamous intraepithelial neoplasia and status of non-endoscopic treatment. zhzdx, 2024, 12(4): 281-286.

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