Abstract：ObjectiveTo study the relationship of ankle-brachial index(ABI) and the urinary albumin,soluble intercellular adhesion molecule-1(sICAM-1) in patients with type 2 diabetic peripheral arterial disease (PAD).MethodsThree hundred and forty-two patients with T2DM were divided into two groups according to the results of ABI,forty-eight cases in PAD group(ABI≤0.9) and two hundred and ninty four cases in non-PAD group(0.9＜ABI≤1.3).At the same time,urinary albumin（μAlb）,sICAM-1,triglyceride (TG),total cholesterol (TC),low density lipoprotein (LDL),high density lipoprotein (HDL),fasting blood glucose (FBG),2-hour postprandial blood glucose (2hBG) of all patients were tested.The value of the two groups were compared by t-test,and the correlations were analyzed by liner-regression analysis.ResultsμAlb［(125.4±108.2)mg,(67.6±55.5)mg,t=5.47,P<0.05］,sICAM-1 ［(278.6±234.1)ng/ml,(161.5±115.2)ng/ml,t=5.01,P<0.05］，the age［(67.7±15.4) years, (54.2±12.8) years,t=3.08,P<0.05］,diabetic history［(15.4±14.1) years,(8.2±7.5) years,t=4.06,P<0.05］,LDL-C［(1.8±1.7)mmol/L,(1.0±1.1)mmol/L,t=6.85,P<0.05］，2hBG［(15.8±5.2)mmol/L,(11.0±4.4)mmol/L,t=2.96,P<0.05］ in PAD group were higher than those in non-PAD group.ABI［(0.8±0.2),(1.2±0.2)］ in PAD group was lower than that in non-PAD group （t=3.53,P<0.05）.Multiple linear regression showed that ABI was correlated with μAlb (r=-0.207,P<0.05）and sICAM-1（r=-0.201,P<0.05）.ConclusionABI can be used as index for screening peripheral arterial disease and diabetic nephropathy in patients with type 2 diabetes,and reflect its inflammatory markers.
