The esophageal motility characteristics and levels of brain-gut peptide in patients with refractory globus
Liu Yao1,Jia Lin1,2
1Department of Gastroenterology,Guangzhou First People′s Hospital,the Affiliated Hospital of Guangzhou Medical University,Guangzhou 511400,China;2Department of Gastroenterology,Guangzhou Nansha Central Hospital Affiliated to Guangzhou First People’s Hospital,Guangzhou 511457,China
Abstract：ObjectiveTo compare the esophageal motility and the levels of brain-gut peptide between refractory globus patients and non-refractory globus patients.MethodsAll subjects underwent high-resolution manometry (HRM) and were detected the levels of brain-gut peptide,which were compared the differences between refractory globus patients and non-refractory globus patients.ResultsRefractory globus patients had higher upper esophageal sphincter (UES) resting press ［(94.97±42.08)mmHg］ compared with non-refractory globus patients ［(73.91±23.47)mmHg,t=2.359,P<0.05］.There were no statistical differences in UES residual pressure［(12.44±8.31)mmHg,(12.66±8.12)mmHg］,UES length［(22.72±10.13)mm,(19.71±7.85)mm］,CFV［(5.47±1.39)cm/s,(5.24±1.40)cm/s］,DL［(6.59±1.29)s,(6.78±1.10)s］,LES［(22.63±10.17)mmHg,(19.56±7.63)mmHg］ between refractory globus patients and non-refractory globus patients (t=0.528,0.471,0.725,0.736,0.486;P>0.05).The level of NPY was lower in refractory globus patients ［(626.26±16.60)ng/L］ than that in non-refractory globus patients ［(641.35±17.45)ng/L (t=2.528,P<0.05)］,but the level of SP was higher in refractory globus patients ［(2386.96±372.68）ng/L］ than that in non-refractory globus patients ［(1607.77±345.91)ng/L］,the difference was statistically different (t=3.728,P<0.05).And no statistical difference was found in calcitonin gene-related peptide (CGRP) between refractory globus patients and non-refractory globus patients (t=0.752,P>0.05).ConclusionCompared with nonrefractory globus patients,refractory globus patients have higher UES resting pressure,higher level of SP and lower level of NPY.
刘尧1贾林1,2. 难治性癔球症患者食管压力特征及血清脑肠肽水平的变化[J]. 中华诊断学电子杂志, 2016, 4(3): 149-.
Liu Yao1,Jia Lin1,2. The esophageal motility characteristics and levels of brain-gut peptide in patients with refractory globus. zhzdx, 2016, 4(3): 149-.
