Abstract：Hashimoto′s thyroiditis (HT), which is an organspecific autoimmune disease characterized by lymphocytic infiltration and thyroid fibrosis, is the most common thyroid disorder causing hypothyroidism currently. At present, the pathogenesis of HT has not been fully elucidated, genetic and environmental risk factors will affect the occurrence of abnormal immune response in thyroid. CD4+T lymphocyte-associated cytokines play an indispensable role in the progression of the HT autoimmune thyroid disease. CD4+T cells can differentiate into two cell forms: the helper T cells and regulatory T cells, and then differentiate into different functional T cells, secreting different cytokines to participate in the body′s immune regulation. A variety of cytokines, such as Interleukin (IL)-6, IL-17, IL-22 and other cytokines participate in and play a role in the progression of HT disease. This article reviews the research progress of the relationship between CD4+T cells and HT.
黄园园 刘亚楠 于世鹏. CD4+T淋巴细胞相关细胞因子与桥本氏甲状腺炎发病机制的研究进展[J]. 中华诊断学电子杂志, 2019, 7(3): 214-216.
Huang Yuanyuan1, Liu Yanan1, Yu Shipeng2. Research progress of CD4+T lymphocytes related cytokines and pathogeneis of hashimoto′s thyroiditis. zhzdx, 2019, 7(3): 214-216.
