Objective To investigate the clinical significance of serum thyrorid hormone levels in schizophrenic patients..Methods The three triiodothyronine (T3),thyroxine(T4),and thyroid stimulating hormone (TSH) level were monitoring by chemilumincence immune in one hundred and fortyfive patients with schizophrenia,and thirty cases of normal healthy people (control group) were considered as control.Studies on the age,course,gender,positive and negative symptoms scale,negative symptoms,positive symptoms,general psychopathology scale were analyzed by Person correlation analysis.ResultsSerum thyroid hormone levels were studied before treatment［（1.27±0.37）nom/L、(97.29±19.69)nmol/L、(1.82±1.11)mU/L］ and in control group［(1.93±0.28)nom/L、(113.51±18.92)nmol/L(2.59±1.10）mU/L］,the difference was statistically significant (t=12.89,5.50,4.57;P<0.05) .The level of serum thyroid hormone was lower in T3 compared different course of the study group and the control group (T3:t=7.16,9.01,8.91,8.90,8.47;P<0.05) in the course of two years of the study group and the control group, the difference was statistically significant (t=2.86,3.93,4.27,4.10;P<0.05),the course of TSH in the study group and the control group 2 years in a statistically significant difference(t=3.42,4.02;P<0.05);in the study group and the control group comparison study of different ages.The level of serum T3,T4 (T3≥20 was lower in case group:t=7.93,8.86,9.71,7.76,9.01;P<0.05;T4 in<50 years old group:t=3.70,4.28,5.04,3.77;P<0.05);TSH≥50 years study in group t=2.91,P<0.05).Psychiatric T3
level and PANSS in positive correlation (r=0.176,P<0.05);T4 level and duration of negative correlation (r=-0.188,P<0.05); mental pathology in TSH level and PANSS in positive correlation(r=0.199,P<0.05),and PANSS negative scores showed a negative correlation (r=-0.202,P<0.05).Conclusion Schizophrenic patients have the hypothalamus-pituitary-thyroid adjustment disorder which associated with the course of disease,mental pathology,negative symptoms.
