The research progress of miRNA and diabetic peripheral neuropathy
Su Chang1, Liang Qiuhua2, Sun Lin3
1Clinical Medical College, Jining Medical University, Jining 272013, China; 2Department of Endocrinology, The Affiliated Hospital of Jining Medical University, Jining 272029, China；3Department of Endocrinology, The First People′s Hospital of Jining, Jining 272002, China
Abstract：Diabetic peripheral neuropathy (DPN) is one of the common complications of diabetes, with clinical manifestations including limb pain, numbness, paresthesia and ulceration. DPN is the main cause of nontraumatic amputation. MicroRNA (miRNA) belongs to noncoding RNA (ncRNA) and is an evolutionarily highly conservative RNA, usually 18-25 bases in length. MiRNA has been reported one after another by regulating the roles of multiple genes in a variety of diseases and cell types, such as cell growth, proliferation, differentiation, apoptosis, posttranscriptional gene regulation, and others. Studies have found that miRNA is closely related to nerve conduction, injury, and apoptosis, so miRNA can be used as biomarkers for the diagnosis and prognosis of DPN and as targets for potential molecular therapy. This article mainly reviews the role of miRNA in DPN and the related research progress based on miRNA therapy.
苏畅 梁秋华 孙琳. 微小RNA与糖尿病周围神经病变研究进展[J]. 中华诊断学电子杂志, 2021, 9(4): 285-288.
Su Chang1, Liang Qiuhua2, Sun Lin3. The research progress of miRNA and diabetic peripheral neuropathy. zhzdx, 2021, 9(4): 285-288.
