Abstract：ObjectiveTo investigate the relationship and significance of serum uric acid （UA） level and the Framingham 10-year risk of coronary heart disease in patients with type 2 diabetes mellitus (T2DM). Methods904 patients with T2DM who were admitted to the Department of Endocrinology, Ninth People′s Hospital (North Hospital) , Shanghai Jiaotong University School of Medicine, from August 2015 to December 2017 were chosen, the serum UA levels and Framingham 10-year risk of coronary heart disease between men and women with T2DM were compared. Patients were divided into 4 groups based on quantiles of serum UA level, Framingham 10year risk of coronary heart disease, and other indicators were compared. T2DM patients were divided into lowrisk group, medium-risk group and highrisk group based on their Framingham risk scores for 10-year coronary heart disease, and serum UA levels and other indicators in each group were compared and analyzed. The risk factors for coronary heart disease in the Framingham 10-year were investigated using Logistic regression. ResultsMen with T2DM had higher serum UA levels ［340.00（287.00,393.00）μmol/L］ and a higher Framingham 10-year coronary heart disease risk ［20(13,31)%］ than women ［305.00（255.00,365.50）μmol/L,15（10,20）%］, and the differences were statistically significant (Z=-6.22，-7.01, all P＜0.01). Based on serum UA level quartiles, Framingham 10-year coronary heart disease risk was 15(8, 20)%, 16(10, 20) %, 20(13, 25) %, and 20(13, 31)% from group 1 to group 4, respectively. Patients with higher serum UA levels had a significantly higher 10-year risk of coronary heart disease (P＜0.05). Patients in the higher Framingham 10year risk groups had significantly higher serum UA levels (P＜0.05). According to a Logistic regression analysis, serum UA level was an independent factor in the Framingham 10-year risk of coronary heart disease (P=0.022, OR=1.003, 95%CI：1.000-1.006). ConclusionSerum UA level is an independent factor in Framingham 10-year risk of coronary heart disease in patients with T2DM， at the same time, serum UA level is positively associated with the Framingham 10-year risk degree of coronary heart disease in T2DM.
叶宽萍 李花 马晓文 刘晓燕 陈凤玲. 2 型糖尿病患者血尿酸水平与 Framingham 十年冠心病发生风险的关系研究[J]. 中华诊断学电子杂志, 2022, 10(3): 145-151.
Ye Kuanping, Li Hua, Ma Xiaowen, Liu Xiaoyan, Chen Fengling. Relationship between serum uric acid level and Framingham 10-year risk of coronary heart disease in patients with type 2 diabetes mellitus. zhzdx, 2022, 10(3): 145-151.
