Abstract：ObjectiveTo explore the clinical characteristics of progressive bilateral medial medullary infarction（BMMI）. MethodsThe clinical data of two patients with progressive BMMI diagnosed in the Department of Neurology, Qingpu Branch of Zhongshan Hospital of Fudan University on December 14, 2021 and May 9, 2022 were chosen to summarize the diagnostic features of BMMI, and the relevant literatures were reviewed. ResultsThe patients were all men between the ages of 50 and 40. Case 1 patient′s first symptom was dizziness, while case 2 patient′s first symptom was dizziness with head and neck pain. Both patients experienced lateral limb weakness within 12 hours of onset, which was exacerbated on the second day. As the disease progressed, both patients developed dysarthria and dysphagia. One week after onset, case 1 patient developed quadriplegia. Two patients were diagnosed with BMMI using head magnetic resonance imaging (MRI), which revealed high signal lesions extending along the midline to the dorsal side, resembling a "heart" or "Y" shape on diffusion weighted imaging（DWI）. ConclusionsQuadriplegia, dysphagia, dysarticulation, deep sensory disorders, and other clinical manifestations of BMMI are common. Because the early symptoms of this disease are mostly atypical, it is critical to improve the head MRI examination as soon as possible to facilitate early diagnosis and treatment guidance.
