Research progress on the role of microglia polarization in the development of neuropathic pain
Bai Luyue1, Zhao Siqi1, Gao Sheng2, Yang Tao1, Meng Chunyang3
1College of Clinical Medicine, Jining Medical University, Jining 272013, China; 2Department of Medicine, Qingdao University, Qingdao 266073, China; 3Department of Spine Surgery, Affiliated Hospital of Jining Medical University, Jining 272029, China
Abstract：Due to its unclear pathological mechanism and poor clinical efficacy, neuropathic pain (NP) has always been a difficult problem in the medical field. Numerous studies have demonstrated that activation of microglia and its consequent anti-inflammatory or pro-inflammatory responses play an important role in the development of NP. In addition, microglia polarization can be divided into pro-inflammatory M1 type and anti-inflammatory M2 type, which play different roles in the regulation of NP. The author mainly examines the relationship between microglia polarization and NP, explores the potential for controlling the microglia's phenotype to affect NP, and looks for novel therapeutic options.
白鲁岳 赵思齐 高升 杨涛 孟纯阳. 小胶质细胞极化在神经病理性疼痛发生发展过程中的作用研究进展[J]. 中华诊断学电子杂志, 2023, 11(1): 33-36.
Bai Luyue1, Zhao Siqi1, Gao Sheng2, Yang Tao1, Meng Chunyang3. Research progress on the role of microglia polarization in the development of neuropathic pain. zhzdx, 2023, 11(1): 33-36.
