Abstract：ObjectiveTo explore the diagnostic characteristics of invasive stratified mucinproducing carcinoma (ISMC). MethodsRetrospective analysis and a study of the literature were performed on the clinical data of a female cervical cancer with ISMC who was admitted to the Department of Gynecology at the Affiliated Hospital of Jining Medical University on September 9, 2021. ResultsIn a nearby hospital, the patient′s cervical cancer screening revealed human papilloma virus (HPV) 33 is positive, while thin-prep cytology test (TCT) showed atypical adenosine cells with no apparent significance. The cervix was big and firm, with a diameter of about 3cm×4cm, according to the gynecological examination. A cervical space-occupying lesion was discovered on a full-body CT scan of the abdomen, and a cervical biopsy revealed squamous cell carcinoma. After a transabdominal radical excision of cervical cancer, postoperative pathology reported a 2cm×2cm×1cm ISMC that had infiltrated the wall of the cervical canal, and affected nerves. In the vascular canal, a tumor thrombus was discovered. P16(+), P63(+), cytokeratin 5/6 (CK5/6)(+), CK7(+), and nuclear proliferationassociated index (Ki-67) (+, ＞75%) were all detected by immunohistochemical labeling. ConclusionsIt′s simple to mistake ISMC for cervical squamous cell cancer. It was possible to distinguish between the two by using immunohistochemical staining.
