Association between serum potassium or hypokalemia and electrocardiographic left ventricular hypertrophy in patients with hypertension and primary aldosteronism
Wang Menghui1, Wang Mengru2, Luo Qin2, Zhu Qing2, Li Nanfang2
1Graduate School of Xinjiang Medical University, Uygur 830001, China; 2Hypertension Center of People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute; National Health Committee Key Laboratory of Hypertension Clinical Research Key Laboratory, Xinjiang Uygur Autonomous Region Hypertension Research Laboratory, Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Uygur 830001, China
Abstract：ObjectiveTo investigate the association between serum potassium/hypokalemia and electrocardiographic left ventricular hypertrophy (ECG-LVH) in patients with hypertension or primary aldosteronism (PA). MethodsA retrospective analysis was performed in 1107 patients with hypertension admitted to the Hypertension Center of Xinjiang Uygur Autonomous Region People′s Hospital between January 2010 and January 2014, who underwent standardized PA screening and simultaneously measured blood potassium and electrocardiogram, and 177 patients were diagnosed with PA. Logistic regression analysis was used to evaluate the association between serum potassium/hypokalemia and ECG-LVH in patients with hypertension or PA. Area under the operating characteristic curve (AUC) was used to assess the accuracy of serum potassium/hypokalemia to predict the ECG-LVH risk. ResultsSerum potassium （OR=0.482, P=0.033） and hypokalemia (OR=1.819, P=0.033） were respectively associated with ECG-LVH, independent of blood pressure, renin activity, and aldosterone-to-renin. And in PA patients, these associations were significantly independent of systolic blood pressure ［（OR=0.070, P=0.004） and （OR=6.472, P=0.007）］, respectively. Moreover, serum potassium can screen for ECG-LVH risk with AUCs of 0.607 and 0.784 in patients with hypertension or PA. When serum potassium ＜3.28mmol/L in patients with PA, the predict value of ECG-LVH risk were high, with sensitivity and specificity of 71.4% and 89.6%, respectively. ConclusionsBoth serum potassium and hypokalemia are independently associated with ECG-LVH, regardless in patients with hypertension or PA. Especially in patients with PA, hypokalemia is associated with cardiac hypertrophy.
王梦卉 王梦茹 骆秦 朱晴 李南方. 高血压及原发性醛固酮增多症患者血清钾
及低钾血症与心电图左心室肥大的关系[J]. 中华诊断学电子杂志, 2024, 12(1): 18-24.
Wang Menghui, Wang Mengru, Luo Qin, Zhu Qing, Li Nanfang. Association between serum potassium or hypokalemia and electrocardiographic left ventricular hypertrophy in patients with hypertension and primary aldosteronism. zhzdx, 2024, 12(1): 18-24.
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