Imaging features of aggressive angiomyxoma and literature review
Zhang Fangfang1, Li Jun1, Zhao Yujie2, Yu Tong3, Ning Chunping1.
1Department of Abdominal Ultrasound, 2Department of Pathology, 3Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China
Abstract:ObjectiveTo investigate the imaging features in patients with aggressive angiomyxoma (AAM). MethodsThe ultrasonography, CT and magnetic resonance imaging (MRI) data of 5 patients with AAM confirmed by postoperative pathology were retrospectively analyzed from January 2016 to November 2023 in the Department of Abdominal Ultrasound of Affiliated Hospital of Qingdao University, and the literature was reviewed. ResultsAll the 5 patients with AAM were female, and the masses were located in the perineum or pelvic cavity, with the maximum diameter of 7-32cm. MRI enhancement showed characteristic layered enhancement of perineal mass in 1 patient. After CT enhancement, 2 cases showed uneven mild or light-moderate enhancement, and the envelope was significantly enhanced, and the internal septa and envelope were significantly enhanced in 1 case. The ultrasonography of 3 cases showed uneven internal echoes, and color Doppler ultrasonography indicated multiple streaks of blood flow signals within the masses, of which 2 cases were hypoechoic masses, with layered distribution high echoes, irregular in shape, and extending to surrounding tissues in a "finger" like or "tongue" like shape. CT angiography (CTA) and CT venography (CTV) showed radial distribution of blood-supply arteries and veins in the mass in 1 case. ConclusionThe diagnosis of AAM should be considered when imaging findings reveals a mass with characteristic internal laminar shape within the perineum or pelvis, or an uneven internal echo that extends to both sides of the pelvis in a "finger like" or "tongue like" shape.
[1]Steeper TA,Rosai J.Aggressive angiomyxoma of the female pelvis and perineum.Report of nine cases of a distinctive type of gynecologic soft-tissue neoplasm[J].Am J Surg Pathol,1983,7(5):463-475.DOI:10.1097/00000478-198307000-00009.
[2]杨晓瑜,肖文波,崔恒,等.侵袭性血管黏液瘤CT和MRI特征分析[J].浙江实用医学,2023,28(3):233-236.DOI:10.3969/j.issn.1007-3299.2023.03.014.
[3]张国平,陈晓莉,陈小龙,等.下肢侵袭性血管黏液瘤三例CT、MRI特点及文献复习[J].中华放射学杂志,2020,54(2):149-152.DOI:10.3760/cma.j.issn.1005-1201.2020.02.012.
[4]唐宁,李长春,廖鑫,等.超声误诊会阴部侵袭性血管黏液瘤1例[J].实用医学影像杂志,2022,23(3):323-324.DOI:10.16106/j.cnki.cn14-1281/r.2022.03.035.
[5]何珂,符小艳,王圣坦.超声误诊宫颈侵袭性血管黏液瘤1例[J].中国医学影像学杂志,2021,29(7):742-743.DOI:10.3969/j.issn.1005-5185.2021.07.021.
[6]Kenny-Moynihan MB,Hagen J,Richman B,et al.Loss of an X chromosome in aggressive angiomyxoma of female soft parts:a case report[J].Cancer Genet Cytogenet,1996,89(1):61-64.DOI:10.1016/0165-4608(95)00350-9.
[7]Wang Y,Bu X,Liu Y,et al.Characteristics and treatment strategies of aggressive angiomyxoma in women:a retrospective review of 87 cases[J].Front Surg,2023(10):966971.DOI:10.3389/fsurg.2023.966971.
[8]Zhao CY, Su N, Jiang YX, et al. Application of ultrasound in aggressive angiomyxoma:eight case reports and review of literature[J].World J Clin Cases,2018,6(14):811-819.DOI:10.12998/wjcc.v6.i14.811.
[9]Tuan TA,Trang BH,Chau N,et al.Imaging features of a rare giant intra-abdominal aggressive angiomyxoma[J].Radiol Case Rep,2024,19(9):4007-4011.DOI:10.1016/j.radcr.2024.06.041.
[10]Surabhi VR,Garg N,Frumovitz M,et al.Aggressive angiomyxomas:a comprehensive imaging review with clinical and histopathologic correlation[J].AJR Am J Roentgenol,2014,202(6):1171-1178.DOI:10.2214/AJR.13.11668.
[11]Qu H,Liu N,Liang HM,et al.Aggressive angiomyxoma of female pelvis and perineum:retrospective study of 17 cases[J].Eur J Obstet Gynecol Reprod Biol,2024(298):165-170.DOI:10.1016/j.ejogrb.2024.05.012.
[12]van Roggen JF,van Unnik JA,Briaire-de Bruijn IH,et al.Aggressive angiomyxoma:a clinicopathological and immunohistochemical study of 11 cases with long-term follow-up[J].Virchows Arch,2005,446(2):157-163.DOI:10.1007/s00428-004-1135-9.
[13]Blandamura S,Cruz J,Faure Vergara L,et al.Aggressive angiomyxoma:a second case of metastasis with patient's death[J].Hum Pathol,2003,34(10):1072-1074.DOI:10.1053/s0046-8177(03)00419-2.
[14]Siassi RM,Papadopoulos T,Matzel KE.Metastasizing aggressive angiomyxoma [J].N Engl J Med,1999,341(23):1772.DOI:10.1056/nejm199912023412315.
[15]高蕾,王志启,程瑾,等.阴道侵袭性血管黏液瘤一例[J].中华妇产科杂志,2020,55(10):723-724.DOI:10.3760/cma.j.cn112141-20200324-00261.