β受体阻滞剂对健康成人64层螺旋CT冠状动脉造影左心室功能的影响

doi:10.3877/cma.j.issn.2095-655X.2014.04.001

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摘要目的研究64层螺旋CT(64SCT)冠状动脉造影，β受体阻滞剂对健康成人左心室功能的影响。方法收集行64SCT冠状动脉造影（64SCTA）检查未发现冠状动脉狭窄的被试178例，其中89例检查前未服用β受体阻滞剂（普萘洛尔），另外89例年龄和性别相匹配的患者（检查前心率>70次/min）服用β受体阻滞剂调整心率。记录用药前后心率（HR）、收缩压（SBP）和舒张压（DBP）及普萘洛尔剂量。测定左心功能指标：舒张末期容积(EDV)、收缩末期容积(ESV)、射血分数(EF)。未服用和服用普萘洛尔组左心功能结果应用配对t检验进行统计分析。结果未服用和服用普萘洛尔两组间的SBP和DBP的差异无统计学意义［分别为（124±14）mmHg和（121±13）mmHg,t=1.04，P>0.05；（81±9）mmHg和（79±10）mmHg,t=1.44,P>0.05;（1mmHg=0.133pKa）］。EDV两组之间差异无统计学意义［分别为（127.5±16.4）ml和（129.8±15.1）ml,t=-1.22,P>0.05］，而ESV和EF在这两组之间的差异有统计学意义［分别为（44.7±12.3）ml和（47.3±13.4）ml，t=2.47,P<0.05;（65.1±8.4）%和（62.0±7.8）%,t=2.39,P<0.05］;服用普萘洛尔组ESV不同程度的增加，而EF下降。结论64SCTA应用β受体阻滞剂，可致ESV增加，EF降低，而SBP、DBP和EDV的差异无统计学意义。

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关键词 ：心室功能, 左, 体层摄影术, 螺旋计算机, 肾上腺素能β受体拮抗剂

Abstract：ObjectiveTo investigate the effects of propranolol on the left ventricular (LV) function by CT coronary angiography.MethodsOne hundred and seventy-eight subjects without coronary artery stenosis were examined by 64SCT coronary angiography (64SCTA).Eight-nine subjects did not take propranolol while another eight-nine age-and gender-matched subjects whose heart rates above 70 beats were chosen to take propranolol.The heart rate, systolic blood pressure (SBP), and diastolic blood pressure (DBP) before and after the administration of propranolol and the dosage of propranolol were recorded.The left ventricular function was calculated by parameters of end-diastolic volume(EDV),end systolic volume(ESV) and ejection fraction(EF).The paired-t test was used to compare the left ventricular function between the two groups (no taking and taking propranolol).ResultsThere were no significant differences in the SBP and DBP between the groups without and with propranolol medication ［(124±14)mmHg and (81±9)mmHg；(121±13)mmHg and (79±10)mmHg,respectively)］.The EDV showed no significant differences between the two groups,but the ESV and EF showed significant differences between the two groups［(44.7±12.3)mL and (47.3±13.4)mL；(65.1±8.4)% and (62.0±7.8)%,respectively)］.ConclusionsTaking propranolol increases ESV and decreases EF, while the SBP, DBP and EDV don′t change.

Key words： Ventricular function,left Tomography,spiral computed Adrenergic beta-antagonists

收稿日期: 2014-06-15

基金资助:国家临床重点专科建设项目(2013年)；湖南省科技厅项目（2009FJ3092）

通讯作者: 彭述平，Email:anyuanzch@163.com

引用本文:

张春红刘军梁立华彭述平. β受体阻滞剂对健康成人64层螺旋CT冠状动脉造影左心室功能的影响[J]. 中华诊断学电子杂志, 2014, 2(4): 245-248.
Zhang Chunhong*,Liu Jun,Liang Lihua,Peng Shuping. The effects of propranolol on the left ventricular function by 64-slice multi-slice computed tomography. zhzdx, 2014, 2(4): 245-248.

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http://www.zhzdxzz.com/CN/10.3877/cma.j.issn.2095-655X.2014.04.001 或 http://www.zhzdxzz.com/CN/Y2014/V2/I4/245

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