汉黄芩素抗炎活性的研究进展

doi:10.3877/cma.j.issn.2095-655X.2025.01.003

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摘要汉黄芩素是一种具有显著抗炎作用的天然黄酮类化合物，主要来源于传统中草药黄芩。在抗炎研究中，汉黄芩素展现出通过多种机制抑制炎症反应的潜力。其作用机制包括抑制促炎细胞因子（如白细胞介素-1、白细胞介素-6、白细胞介素-2、肿瘤坏死因子α）的生成，调控核因子κB和促分裂原活化的蛋白质激酶等炎症信号通路，诱导炎症细胞凋亡，并增强自噬清除受损细胞。汉黄芩素在类风湿性关节炎、炎症性肠病、动脉粥样硬化等多种炎症性疾病中发挥治疗潜力。笔者主要综述汉黄芩素的抗炎机制及其在不同疾病中的应用前景，为未来临床应用提供理论依据。

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关键词 ：汉黄芩素, 黄酮类化合物, 抗炎作用, 炎症因子, 信号通路

Abstract：Wogonin, a natural flavonoid compound with significant anti-inflammatory properties, which is primarily derived from the traditional Chinese herb Scutellaria baicalensis (Huangqin). In studies of its anti-inflammatory effects, Wogonin has demonstrated potential in inhibiting inflammatory responses through multiple mechanisms. These mechanisms include suppressing the production of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-6, IL-2 and tumor necrosis factor-alpha (TNF-α), regulating inflammatory signaling pathways such as nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathway, inducing apoptosis of inflammatory cells, and enhancing autophagy to clear damaged cells. Wogonin has shown therapeutic potential in various inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis. This paper reviews the anti-inflammatory mechanisms of Wogonin and its application prospects in different diseases, providing a theoretical basis for future clinical applications.

Key words： Wogonin Flavonoid Anti-inflammatory effect Inflammatory factor Signal pathway

收稿日期: 2024-09-28

基金资助:山东省中医药科技重点项目（Z-2022081）；济宁市重点研发计划项目（2022YXNS003，2023YXNS031）

通讯作者: 甘立军，Email: ljdoctor1@163.com

引用本文:

李忠鑫陈雪英甘立军. 汉黄芩素抗炎活性的研究进展[J]. 中华诊断学电子杂志, 2025, 13(1): 20-25.
Li Zhongxin1, Chen Xueying2, Gan Lijun2.. Advances in the study of the anti-inflammatory activity of Wogonin. zhzdx, 2025, 13(1): 20-25.

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