Abstract：ObjectiveTo study the change of age-related regulatory T cells and its relationship with the high incidence of lung cancer in the elderly patients.MethodsTo set up Lewis lung cancer model，thirty-six C57BL/6 mice were divided into six groups according to the different months of age.The change of CD4+CD25+Foxp3+Treg cells in spleen was evaluated among the six groups by flow cytometry method.ResultsThe number of CD4+CD25+Foxp3+ Treg cells was higher in tumor group (7.96±3.22) than that in healthy group（2.56±0.95） at the same age (CD4+CD25+Foxp3+/CD4+,t=4.33,P＜0.05).Besides,in the healthy groups,there was statistical difference among the three groups (F=23.13,P＜0.05).Accumulation of the CD4+CD25+Foxp3+ Treg cells were accompanied with age,the elderly mice contained a significantly larger population of CD4+CD25+Foxp3+ Treg cells in their spleen than those in younger counterparts,and the elderly tumor group had the highest expression（11.97±3.62）.ConclusionThe results suggest a close relationship between the age-related changes of treg cells aging and the incidence of lung cancer in the elderly.
祝丽晶 仇祝强 侯盼飞. 调节性T细胞增龄性变化与老年肺癌发病率的关系[J]. 中华诊断学电子杂志, 2015, 3(1): 12-14.
Zhu Lijing,Qiu Zhuqiang,Hou Panfei. The relationship between aged-related change of regulatory T cells and incidence of lung cancer in the elderly. zhzdx, 2015, 3(1): 12-14.
